furosemide

Buy Furosemide Injection (50 mg/mL) is a potent loop diuretic that is a derivative of anthranilic acid. It is an effective diureticsaluretic for use in the treatment of acute non-inflammatory tissue edema in dogs and horses, and for usein the treatment of edema (pulmonarycongestion, ascites) associated with cardiac insufficiency in dogs. Administer IV or IM.

ITEM# DESCRIPTION SIZE

501070 Furosemide Injection 100 mL

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION: Furosemide is a potent loop diuretic which is a derivative of anthranilic acid.

The struture is:
Chemical Name: 4-Chloro-N-furfury|-5-sulfamoylan thranilic acid. Furosemide is pharmacodynamically characterized by the following.

1) Administered intramuscularly, it begins to actin about minutes, and diuretic response is produced
When administered intravenously, the response is in about 5 minutes.
2) Is a loop diuretic which inhibits reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion.
3) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold.
4) A high degree of efficacy, low inherent toxicity and a high therapeutic index.

EACH ML CONTAINS: 50 mg furosemide as a monoethanolamine salt, myristyl-gamma picolinium chloride 0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with sodium chloride 0.2% in water for injection, pH adjusted with sodium hydroxide and/ or hydrochloric acid.

ACTIONS: The therapeutic efficacy of Furosemide Injection is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug’s rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or
crystallurid. Furosemide has no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity either in the presence of acidosis or alkalosis.1 3 4 5 6

INDICATIONS: Dogs and Horses: Furosemide Injection is an effective diuretic-saluretic for use in the treatment of acute non inflammatory tissue edema in dogs and
horses, and for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency in dogs

In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy in either dogs or horses is determined by the clinical pathology producing the edema.

DOSAGE AND ADMINISTRATION: Dogs-Administer intravenously or intramuscularly 0.25 to 0.50 mL per 10 pounds body weight once or twice daily at 6 to 8 hour intervals.
The dosage should be adjusted to the individual’s response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1.0 mg per pound of body weight. The established effective dose should be administered or twice daily.