A clear yellow aqueous solution for parenteral administration containing as active ingredients per ml: Sulfadiazine 200mg and Trimethoprim 40mg. Preservative: Chlorocresol 1mg/ml Antioxidant: Sodium Formaldehyde Sulphoxylate Dihydrate 1mg/ml
Norodine 24 is indicated in the treatment of acute, subacute and chronic conditions of bacterial origin in horses, cattle, pigs, dogs and cats.
The therapeutic spectrum includes both Gram-negative and Gram-positive bacteria including Streptococci, Staphylococci, Actinobacilli, Actinomycae, Salmonella, Pasteurella, Pneumococci, Proteus, E. coli, Corynebacteria, Vibrio, Bordetella, Brucella, Klebsiellae and Haemophilae.
It is also indicated in species where there may be an existing antibiotic drug resistance. Norodine 24 may be administered in respiratory infections of bacterial origin including rhinitis, pneumonia, bronchitis and in bacterial infections secondary to viral disease such as viral pneumonia or mycoplasma infections. It is also indicated in urogenital tract infections (cystitis, vaginitis, urethritis, nephritis and metritis) and alimentary tract infections (including neonatal diarrhoea and salmonellosis). Other infections include foul-in-the-foot, severe mastitis, bacterial agalactia of sows, and infections of eye, ear and mouth.
Dosage Cattle and pigs: 1ml per 16kg bodyweight daily by intramuscular or slow intravenous injection. Norodine 24 may be administered by intravenous injection when rapid blood levels of sulfadiazine and trimethoprim are required. Horses: 1ml per 16kg bodyweight by slow intravenous injection. Dogs and cats: 1ml per 8kg bodyweight, by subcutaneous injection only. The recommended site in dogs is the loose skin at the top of the neck. A single injection may be sufficient in uncomplicated conditions, but in severe infections they may be repeated daily until two days after the symptoms resolve, up to a maximum of 5 days. An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.
Withdrawal Period Cattle: Meat – 12 days Milk – 48 hours Pigs: Meat – 20 days Milk for human consumption must not be taken from a cow during treatment. Animals must not be slaughtered for human consumption during treatment. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.
Contra Indications Norodine 24 is contraindicated in animals with known sulfonamide sensitivity, severe liver parenchymal damage, or blood dyscrasias. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
Adequate drinking water should be available during the therapeutic effect of the product. Do not administer to horses exhibiting drug-induced cardiac arrhythmias. Such arrhythmias may be associated with the administration of certain anaesthetic and sedative agents.
Anaphylactic shock, potentially fatal, has been observed on rare occasions following administration of potentiated sulfonamide preparations, particularly by the intravenous route. Veterinary surgeons should be mindful of this possibility during the injection process. For intravenous administration the product should be warmed to body temperature and injected slowly over as long a period as is reasonably practical. At the first sign of intolerance the injection should be interrupted and shock treatment initiated.
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