Saizen human growth hormone (HGH) is a somatropin. It is manufactured using recombinant DNA technology. Somatropin is produced naturally by the body. They are responsible for growth. Sometimes, the body does not produce enough of this hormone leading to stunted growth. It is in such cases that doctors can recommend Saizen for adults.


Saizen is prescribed for adults who have growth hormone deficiency (GHD). This condition can exist by itself or along with other hormone deficiencies.

Growth hormone deficiency comes in two ways, adult and childhood onset. It can be a result of genetic factors or organic disease.

  1. Adult-onset
    Adult-onset means that the GHD began at the adult stage. Hormone deficiencies can be a result of factors like hypothalamic and pituitary diseases. It can also be a result of trauma or radiation therapy.
  2. Childhood-onset
    People who grew up with GHD may continue to suffer from the condition as adults. Since not all who suffered from the condition as children will experience GHD as adults, hormone provocative tests may be required to confirm the presence of the condition.


Saizen hgh may be harmful to patients who suffer from other conditions. The doctor usually considers the medical history and will not recommend Saizen for adults to;

  • Patients who are hypersensitive to somatropin. In such cases, alternative solutions can be explored for patients with HGD.
  • Patients who are sensitive to benzyl alcohol. Benzyl alcohol is a component of the bacteriostatic water used to reconstitute Saizen injections.
  • Any patients who suffer from acute illnesses like complications arising from open heart surgery, multiple trauma from accidents, severe respiratory failure, and abdominal surgery.
  • Patients who suffer from diabetic retinopathy should not use Saizen.

HGD can be a result of pituitary or other brain tumors. Before commencing treatment with somatropin, any pre-existing malignant tumors should be inactive, and their treatment should be over. Saizen HGH injections can only be used when the above conditions have been satisfied, or it has been ascertained that the HGD is not a result of tumors.

Symptoms of growth hormone deficiency

Tests can detect growth hormone deficiency in adults. The symptoms vary and can indicate other conditions. The common signs of HGD include:

  • Baldness in men
  • Depression
  • Anxiety
  • Thin, dry skin
  • Low libido and reduced sexual ability
  • Reduced muscle strength and mass, often accompanied by an accumulation of fat, especially around the waist.
  • A spike in cholesterol levels
  • Increased levels of triglyceride
  • Lack of concentration and forgetfulness
  • Insulin resistance
  • Osteoporosis and reduced bone density
  • Abnormal sensitivity to heat and cold
  • Feeling of weakness

Apart from HGD, doctors can prescribe Saizen injections for adults for;

  • Short bowel syndrome
  • Muscle wasting disease. This can be a result of HIV/AIDS

How Saizen HGH works

Saizen growth hormone supplies the body with the much-needed ingredient that is responsible for:

  • Tissue growth
    Spurs tissue growth and regeneration in adults. These include muscles, skeletal mass, and internal organs.
  • Protein metabolism
    Increased protein metabolism is another effect of Saizen hgh injections. This leads to better absorption of nitrogen by the body.
  • Carbohydrate metabolism
    Somatropin plays a role in carbohydrate metabolism. It leads to better insulin levels in adults.
  • Lipid metabolism.
    Saizen growth hormone helps reduce body fat. Long-term administration results in decreased cholesterol and body fat levels. It also leads to increased retention of minerals like phosphorus, potassium, and sodium.


Saizen is administered only on prescription. Human growth hormone can cause undesirable effects on people who do not need it. Saizen is only administered by injection. If it were administered orally, the stomach would digest it into its impotent components.

When administered by subcutaneous injection, the doctor gives a strict schedule to be followed. Overdosing must be avoided, and the tight timelines must be adhered to.


Dosage can be administered using two approaches, a weight based and non-weight based method.

  • Weight-based regimen
    In this method, the daily dosage is capped at 0.005mg per kg was given daily through subcutaneous injection. The dosage can be increased to double at 0.01 mg per kg after four weeks depending on the patient’s condition.
  • Non-weight based regimen
    An alternative dosage can start at between 0.15 to 0.30 mg per day. The daily dosage can then be raised by between 0.1 to 0.2 mg per day in the course of the treatment. It can also be decreased in case the patient shows adverse reactions.

Considerations when determining the dosage include health, the severity of side effects for an individual and other medications.

Saizen description

Saizen comes as a white powder it comes in 5mg and 8.8 mg vials. These vials must be stored at room temperatures of between 15 to 30 degrees Celsius. Before administration, it is reconstituted to liquid form using bacteriostatic water. The bacteriostatic water has 0.9% benzyl alcohol which is a microbial preservative. Once Saizen has been reconstituted, it must be stored under refrigeration at 2 to 8 degrees Celsius for up to 21 days.


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